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In co-supplementation, it is impossible to isolate individual results of one ingredient if it not examined individually. One widespread co-supplementation was Vitamin C and Vitamin E, which have been examined in a meta-analysis for their results on HOMA-IR however concluded no benefit. In the case of reporting a reduction of secondary symptoms of diabetes, corresponding to improved glycemic control, we're unsure if this was the first aim of the examine. It is unclear why these secondary signs can be reported...